Olfactory Receptor Neurons in Fish : Structural , Molecular and Functional Correlates
نویسنده
چکیده
In rodents, the olfactory system is segregated into the main olfactory epithelium (OE) and into the vomeronasal organ (VNO), the former populated by ciliated olfactory receptor neurons (ORNs) expressing the G-protein subunit Gαolf and OR-type odorant receptor molecules, the latter housing microvillous receptor neurons (VRNs) expressing Gαo and Gαi and V1R, V2R and V3R receptor molecules. Projections of ORNs and VRNs target distinct areas in the olfactory bulb (OB) and the accessory olfactory bulb (AOB), respectively. Differing from the situation in rodents, the fish OE contains three different types of ORNs: ciliated, microvillous and crypt cells. These three types of ORNs are intermingled in one epithelium. Recently, Nikonov and Caprio (2001) showed that in catfish responses to biologically relevant stimuli form a consistent map in the OB. The present study asked whether a distinct function can be attributed to the different types of ORNs; whether the different types of ORNs utilize different G-protein α-subunits and different OR or V2R receptor molecules; and whether the different morphological types of ORNs are distributed homogeneously across the olfactory lamellae.
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